| 제목 |
Ten-year follow up and all-cause mortality from Korean Longitudinal Study on Health and Aging |
| 소속 |
Seoul National University Bundang Hospital, Department of Rehabilitation Medicine1, Seoul National University Bundang Hospital, Department of Internal Medicine2, Seoul National University Bundang Hospital, Department of Psychiatry3 |
| 저자 |
Ga Yang Shim1*, Jae-Young Lim1†, Hak Chul Jang2, Ki Woong Kim3 |
| 사사 |
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Introduction
In 2019, the Asian Working Group for Sarcopenia (AWGS 2019) updated their original definition of sarcopenia. Sarcopenia is a risk-factor for all-cause mortality among older adults. The aim of this study is to review the prevalence of sarcopenia using AWGS 2019 criteria and investigate long-term all-cause mortality risk in the Korean Longitudinal Study on Health and Aging (KLoSHA) in the community-dwelling elderly.
Methods
The data was derived from the KLoSHA, a community-based prospective study of Korean people aged 65 years and over. Handgrip strength, muscle mass and physical performance were measured using a hand dynamometer, dual energy X-ray absorptiometry (DXA) and Short Physical Performance Battery (SPPB), respectively. Sarcopenia, possible sarcopenia and severe sarcopenia was determined based on the AWGS 2019 definition. The outcomes data of 10 years follow-up were collected from chart review. The association of HGS, AMI, SPPB with mortality were analyzed using Cox regression.
Results
The basic characteristics of 365 patients are shown in Table 1. The prevalence of sarcopenia was 16.7% and more frequent in male. However, possible sarcopenia was more frequent in female. 183 patients were followed and 55 patients were died during the periods. Table 2 showed outcomes of 10-year follow up. There was no statistically significant between all-cause mortality and sarcopenia. The occurrence of cancer was 33.3%. Total SPPB score, which standed for physical performance, was associated with a mortality risk (HR 0.815, 95% CI 0.721-0.920, P=0.001).
Conclusion
With increasing number of older adults, sarcopenia is a emerging serious clinical problem among older adults. In this long-term follow up study, sarcopenia is associated with all-cause mortality and lower physical performance significantly decrease the survival rate in older community-dwelling patients. |
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Table 1. Basic characteristics of the patients
Table 2. Outcomes of 10-year follow up (N=183)
Table3. Cox regression of risk factor for mortality
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