| 제목 |
Secretome from neural precausor cells attanuated neuronal injury in pMCAO rat model |
| 소속 |
Wonju Severance Christian Hospital, Department of Rehabilitation Medicine1, Yonsei University Wonju College of Medicine, Department of Anatomy2, Catholic Kwandong University College of Medicine, Department of Biomedical Sciences3 |
| 저자 |
Ji Yoon Jang1*, Ji Hyun Kim1†, Ji Yong Lee2, Han-soo Kim3, Jun Yoon Park1, Ji Seon Hong1 |
We previously showed that the transplantation of pluripotent stem cell-derived neural precursor cells (NPCs) improve functional outcomes in a rat model of ischemic stroke.
NPCs exerted the beneficial effects, in part, through paracrine mechanism. In this study, we investigated the ability of NPC secretome to improve behavioral function in a rat stroke model. Data showed that rats administrated with NPC secretome are superior to those treated with blank in behavioral function throughout time points.
To investigate its underlying events, immunohistochemical (IHC) analysis was performed on rat ischemic brains. IHC analyses showed that NPC secretomes reduced inflammation, enhanced angiogenesis with increased endogenous neurogenesis in rat injured brain.
In conculsion, NPC secretome promotes the functional recovery of damaged stroke brain via modulation of anti-inflammation, angiogenesis and neurogenesis. Thus, NPC secretome closely recapitulateds the effects seen upon NPC transplantation |
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