| 제목 |
ActiView II: A MATLAB-based Toolbox of Real-time Cortical Activation Viewer Based on f-NIRS |
| 소속 |
Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute1, DongSeo University, Department of Radiological Science at Health Sciences Division2, Sungkyunkwan University, Department of Health Sciences and Technology, Department of Medical Device Management & Research, Department of Digital Health, SAIHST3 |
| 저자 |
Gihyoun Lee1*, Young-Jin Jung2, Jungsoo Lee1, Jinuk Kim1,3, Yun-Hee Kim1,3† |
Objective
Brain cortical activation analysis is important for understanding the causes of neurological disorders and relevant brain mechanisms. The main contribution of the present paper is an introduction of a new real-time cortical activation view toolbox in MATLAB for functional near-infrared spectroscopy (f-NIRS) referred to as ActiView II that has an interactive graphical user interface (GUI). ActiView II allows functions not only analyzing hemodynamic time-series data but also representing functional activities with a three-dimensional standard head model. The remainder of this study introduces the implemented functions of ActiView II and representative experimental examples of the toolbox.
Materials and Methods
ActiView II requires a MATLAB (MathWorks, Natick, MA, USA) environment, and it provides the MATLAB GUIDE that allows users to intuitively analyze the cortical activities in real-time environments. In order to describe the function of the ActiView II toolbox, the experimental task paradigm was chosen as the finger-tapping task combined with one minute of a baseline f-NIRS data and finger-tapping task. Seven subjects (24.1±5.64 years, five males, two females, and right-handed) were recruited. All subjects were healthy with no brain injury, neurologic, or psychiatric disease profiles. Informed consent was obtained from all subjects. f-NIRS data acquisition was performed with an fNIRS brain imaging system (NIRSport 8–8, NIRx Medizintechnik GmbH, Berlin, Germany).
Results
In order to estimate the hemodynamic response signals, two wavelengths (760 nm and 850 nm) of LED light were used for this experiment, and the differential path length factors (DPFs) were set to 6.297 for the wavelength of 760 nm, and 5.234 for the wavelength of 850 nm, as recommended from the user manual of NIRSport. A block design was used that the fNIRS signal of the subjects was measured where three activation trials were alternated, while repetitive finger tapping was performed simultaneously with the use of both hands during a 20 s period and 20 s period rest block. The result by using ActiView II shows the cortical activation in the primary motor cortex in both hemispheres in real-time.
Conclusions
We have developed a new MATLAB toolbox, referred to as ActiView II that can be used to represent functional cortical activities for f-NIRS in real-time. It is easy and simple to use for viewing the head model and functional cortical activities. ActiView II was used to estimate its strengths and to validate its performance for brain activation in real-time. We demonstrated the necessity and performance of ActiView II with the use of the basic experimental paradigm of f-NIRS. Given that the technique of the real-time brain signal analysis can be used for the understanding of neuroscience and neurological clinical studies, ActiView II has tremendous potential for use in hemodynamic brain signal research of f-NIRS. |
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