| 제목 |
White matter abnormalities in spontaneous SAH: a tract-based spatial statistics study |
| 소속 |
College of Medicine, Yeungnam University, Department of Physical Medicine and Rehabilitation1 |
| 저자 |
Sung Ho Jang1†, Sung Jun Lee1†, Kyu Tae Choi1*† |
Introduction: Diffusion tensor imaging (DTI) has a distinct advantage in its ability to identify microstructural white matter abnormalities. However, little has been reported about the effect of spontaneous subarachnoid hemorrhage (SAH) in the whole white matter. In this study, by using tract-based spatial statistics (TBSS), we investigated white matter abnormalities in patients with spontaneous SAH following aneurysmal rupture.
Methods: Sixteen patients with spontaneous SAH due to aneurysmal rupture and 18 age- and sex-matched healthy control subjects were recruited to this study. Voxel-wise statistical analysis of fractional anisotropy (FA) data was performed by using tract-based spatial statistics (TBSS) as implemented in the FMRIB Software Library. We calculated mean FA values across the tract skeleton and within 48 regions of interest (ROIs) based on the intersections between the FA skeleton and the probabilistic Johns Hopkins University white matter atlases.
Results: Comparing the patient and control groups, the FA values of 44 ROIs among the 48 ROIs showed significant differences (p < 0.05). However, significant differences were not observed in the remaining four ROIs (both retrolenticular parts of the internal capsule, the right superior longitudinal fasciculus, and the right superior corona radiata) (p > 0.05).
Conclusion: By undertaking TBSS analysis, we detected wide-ranging white matter abnormalities in patients with spontaneous SAH. |
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Results of tract-based spatial statics analysis comparing fractional anisotropy (FA) values of the patient and control groups. The blue voxels represent areas of significantly higher mean FA values in the control group compared to the patient group.
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