| 제목 |
Relationship between hyperhidrosis and hypothalamic injury in patients with mild TBI. |
| 소속 |
College of Medicine, Yeungnam University, Department of Rehabilitation Medicine1 |
| 저자 |
Sung Ho Jang1†, Hyeok Gyu Kwon1†, Min Young Lee1*† |
Objectives: Hyperhidrosis is clinical symptom of various diseases and is an important clinical feature of paroxysmal sympathetic hyperactivity (PSH). Traumatic brain injury (TBI) is known to be most common condition associated with PSH, and PSH has been mainly reported in moderate and severe TBI. However, very little has been reported on PSH or hyperhidrosis in mild TBI patients. In this study, we used diffusion tensor imaging (DTI) to investigate the relationship between hyperhidrosis and hypothalamic injury in patients with mild TBI.
Methods: Seven patients with hyperhidrosis after mild TBI and 21 healthy control subjects were recruited for this study. The Hyperhidrosis Disease Severity Scale was used for evaluation of sweating at the time of DTI scanning. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) DTI parameters were measured in the hypothalamus.
Results: In the patient group, the FA values for both sides of the hypothalamus were significantly lower than those of the control group (p < 0.05). By contrast, the ADC values for both sides of the hypothalamus were significantly higher in the patient group than in the control group (p < 0.05).
Conclusions: In conclusion, we detected hypothalamic injuries in patients who showed hyperhidrosis after mild TBI. Based on the results, it appears that hyperhidrosis in patients with mild TBI is related to hypothalamic injury. |
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Region of interest for the hypothalamus and results of independent t-test comparison of the fractional anisotropy and apparent diffusion coefficient values between the patient and control groups.
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