| 소속 |
College of Medicine, Chungnam National University, Daejeon, Republic of Korea , Department of Rehabilitation Medicine1, Chungnam National University Hospital, Daejeon, Republic of Korea, Chungnam Regional Cardiocerebrovascular Center2 |
Objective
The reliability of the event-related potential (visual and auditory) test is evaluated for patients with subacute stroke, and the validity of the cognitive function of the event-related potential is evaluated.
Method
We recruited 20 subacute ischemic stroke patients over the age of 19 and with an MMSE score of 11-26. K-MMSE (Korean-mini mental stat examination) and K-MoCA (Korean-Montreal Cognitive Assessment) of all participants were tested. The resting-state EEG and P300 wave using an auditory and visual oddball paradigm were measured at baseline (i.e., within 4 weeks poststroke) and once again in 24 hours. We calculated the brain symmetry index (BSI) and directional BSI (BSIdir) over different frequency bands (1-25 Hz, delta, theta) and delta/alpha ratio (DAR). The intra-rater reliability and validity of the P300 latency, amplitude, BSI, BSIdir and DAR were measured by intra-class correlation (ICC) analysis and by Pearson`s correlation coefficient analysis, respectively.
Result
P300 latency showed good reliability (ICC = 0.79, p < 0.05). As to P300 amplitude, reliability was good with ICC of 0.76 (p < 0.05). The intra-rater reliability of BSI, BSIdir and DAR was good ICC, (0.81, 0.80, 0.77, p < 0.05), respectively. Pearson correlation analysis demonstrated that the BSI, affected DAR was significantly correlated with the K-MMSE score (Pearson r=0.71, r=0.64, p<0.05) respectively. P300 amplitude, latency, BSI, BSIdir and DAR were correlated with K-MMSE and K-MoCA, especially affected DAR and BSI showed strong validity.
Conclusion
P300, BSI, and DAR are consistent and highly related to the patient's cognitive function, so it can be used as an electrophysiological function test for stroke patients. It is necessary to clarify the relevance of stroke patients to functional recovery.
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