| 제목 |
Factor analysis to affect muscle characteristics in DM patients: A pilot study |
| 소속 |
Inha University Hospital, Department of Rehabilitation Medicine1 |
| 저자 |
Chan Hyuk Park1*, Chang Beom Kim1, Hyung Ryu1, Chang Hwan Kim1, Myeong Ok Kim1† |
Objectives: Diabetic polyneuropathy (DPN) is peripheral nerve dysfunction, and one of the major complications with diabetic retinopathy and diabetic nephropathy. DPN in patients with DM is observed in 7% of cases within one year and more than 50% after 25 years. DPN presents with sensory disturbances. Afterward, motor disturbances can be generated in more severe conditions, inducing distal weakness and muscle atrophy of the lower leg and foot. The aims of this study represented correlation between parameters of DM and muscle characteristics measured during isometric contraction using surface electromyography (sEMG) in patients with DPN. Results expected to provide effective exercise program as well as EMG-based methods for quantification in muscle fatigue assessment for patients with DPN.
Methods: Fifteen of twenty-five patients with DM diagnosed DM neuropathy (DPN) with nerve conduction study (NCS) in upper and lower extremities, and calculated composite score (CS) after history taking. They performed laboratory test including HbA1c, fasting plasma glucose (FPG), total cholesterol, HDL, and LDL. Calf circumference (CC) for atrophy and surface EMG for the quantification for strengthening (RMS) and fatigue (MDF and MNF) were used. RMS, MDF, and MNF on medial gastrocnemius (GCM) were measured by isometric maximal voluntary contracture of plantarflexion (Table 1). This study showed the correlation and regression analysis between these parameters and characteristics of muscle.
Results: The duration of DM was not only related to fatigue and CC of muscle, but CS (p<0.01). However, CC or CS did not affected fatigue. CC was associated with HbA1c (p<0.05, Table 2.) Multivariate linear regression analysis depending on duration of DM was a statistically significant in MDF and MNF (p<0.01, Table 3).
Conclusions: We found that the duration of DM affected the fatigue of muscle greatly, and recommend the steady endurance exercise in patients with DM.
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Clinical characteristics of DM patients with or without DPN. (*p < 0.05, **p<0.01)
The correlation between parameters in patients with DPN. (*p < 0.05, **p<0.01)
Linear regression analysis in patients with DPN. (*p<0.05, **p < 0.01)
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