| 제목 |
Laterality of Cerebellar Afferent and Efferent Pathways in a Healthy Right-handed Population |
| 소속 |
Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Department of Rehabilitation Medicine1, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Department of Rehabilitation Medicine2, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Department of Family Medicine3 |
| 저자 |
Youngkook Kim1*, Sun Im2, Se-Hong Kim3, Mi-Jeong Yoon1, Da-ye Kim1, Yeun Jie Yoo1, Sun Jae Won1, Geun-Young Park2† |
Objective: The cerebellum communicates with the cerebral cortex through the cortico-ponto-cerebellar tract (CPCT, cerebellar afferent) and the dentato-rubro-thalamo-cortical tract (DRTCT, cerebellar efferent). This study explored the laterality of CPCT and DRTCT in a right-handed population.
Methods: Forty healthy right-handed subjects who underwent diffusion tensor imaging (DTI) were retrospectively enrolled. Bilateral CPCT, DRTCT, and the corticospinal tract (CST) were reconstructed using probabilistic diffusion tensor tractography (DTT). Tract volume (TV) and fractional anisotropy (FA) were compared between dominant and non-dominant tracts. To determine age-related differences, the TV and FA were compared between three age groups (20–40, 41–60, and 61–80years).
Results: TV and FA of non-dominant CPCT were higher than those of dominant CPCT, and the dominant CST was higher than the non-dominant CST. The TV and FA of DRTCT showed no side-to-side difference. The 61–80years age group had the highest TV of the dominant and non-dominant DRTCT among the three groups and the highest FA of the non-dominant CPCT and DRTCT.
Conclusions: The results revealed normal asymmetric patterns and age-related changes of CPCT and DRTCT using probabilistic DTT. Normal characteristics of cerebro-cerebellar structural connectivity will be valuable to evaluate structure-function relationships and reorganization after lateralized brain injury.
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The cerebellum communicates with the cerebral cortex through the cortico-ponto-cerebellar tract (CPCT, cerebellar afferent) and the dentato-rubro-thalamo-cortical tract (DRTCT, cerebellar efferent). We reconstructed bilateral CPCT and DRTCT using probabilistic diffusion tensor tractography. The CPCT was biased to the non-dominant cerebellar hemisphere, but the DRTCT did not show any significant laterality.
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