| 소속 |
Jeju National University School of Medicine, Regional Rheumatoid and Degenerative Arthritis Center, Jeju National University Hospital, Jeju, Repubic of Korea, Department of Rehabilitation Medicine1, Jeju National University School of Medicine, Regional Rheumatoid and Degenerative Arthritis Center, Jeju National University Hospital, Jeju, Repubic of Korea, Department of Orthopedic Surgery2 |
| 저자 |
So Young Lee1*, Bo Ryun Kim1†, Sang Rim Kim2, Kwang Woo Nam2, Yong-Geun Park2, Min Ji Suh1, Won Bin Kim1, Youn Ji Kim1 |
Objective
This study was undertaken to investigate the prevalence of osteosarcopenia and its impact on physical function, quality of life and pain in patients with end-stage knee osteoarthritis.
Methods
In this cross-sectional study, we assessed a total of 578 patients (77 males and 501 females; average age 71.47±5.72 years) who were diagnosed with end-stage knee osteoarthritis (OA). We divided patient into four groups according to the presence of osteoporosis and sarcopenia(defined as a loss of skeletal muscle mass by Bioelectrical Impedance Analysis). The concept of osteosarcopenia is defined as patients with osteoporosis and sarcopenia. All patients completed performance-based physical function tests including stair climbing test (SCT), 6-minute walk test (6MWT), timed up and go test (TUG), instrumental gait analysis for spatio-temporal parameters. Self-reported physical function and pain were measured using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS), and self-reported quality of life was measured using the EuroQOL five dimensions (EQ-5D) questionnaire.
Results
Osteoporosis alone was diagnosed in 191 subjects (33%), sarcopenia alone in 23 (4%), and osteosarcopenia in 13 (2.2%). Among 13 patients with osteosarcopenia, 11(84.6) were females and 2(15.4) were males. In the analysis of variance (ANOVA), osteosarcopenia group exhibited significantly higher scores in SCT-ascent, SCT-descent, TUG, and lower scores in 6MWT, gait speed, cadence and EQ-5D in other groups (P<0.05). After adjusting for age, sex, BMI by the logistic regression, SCT-descent (β=0.158, p<0.001, R2=0.13), SCT-descent (β=0.169, p<0.001, R2=0.118), 6MWT (β=0.091, p=0.027, R2=0.027), TUG (β=0.14, p=0.001, R2=0.128), EQ-5D (β=-0.14, p=0.001, R2=0.033), WOMAC pain(β=0.158, p<0.001, R2=0.13), gait speed (β=-0.138, p=0.001, R2=0.085) and cadence (β=-0.131, p=0.002, R2=0.039) were significantly associated with patients with osteosarcopenia (OR=1.040, 95% CI 1.010-1.071, p=0.010).
Conclusions
This study confirmed the prevalence of osteosarcopenia could be associated with the performance-based and self-reported physical function, and quality of life in patients with end-stage knee OA. |
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Table1. Demographic characteristics of the subjects (N=578)
Table2. Demographic data and performance-based physical function, self-reported physical function, quality of life and pain in patients with end-stage knee osteoarthritis according to groups (N=578).
Table3. Factors of performance-based physical function, self-reported physical function, quality of life and pain associated with osteosarcopenia in patients with end-stage knee osteoarthritis by logistic regression analyses adjusting for age, sex, BMI.
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