| 제목 |
Relationship between low handgrip strength and chronic kidney diseases: KNHANES 2014-2017 |
| 소속 |
Seoul National University Hospital, Department of Rehabilitation Medicine1, SMG-SNU Boramae Medical Center, Department of Rehabilitation Medicine2, Seoul National University Bundang Hospital, Department of Rehabilitation Medicine3 |
| 저자 |
Yae Lim Lee1*, Shi-Uk Lee2, Se Hee Jung2, Jae-Young Lim3, Sang Yoon Lee2† |
Introduction: Accelerated loss of muscle mass is common in patients with the chronic kidney disease (CKD). Various factors associated with CKD such as nutritional deficiencies, metabolic acidosis, and chronic inflammation contribute to muscle wasting. This study investigated the relationship between CKD and handgrip strength (HGS) in Korean population.
Methods: This was a population-based, cross-sectional study using a nationally representative sample of 24,785 subjects aged ≥19 years from the Korea National Health and Nutrition Examination Surveys of 2014–2017. HGS was measured using a digital hand dynamometer and the cut-offs for grade I and II low HGS were presented by deriving -1 and -2 standard deviations values of sex-matched healthy young adults (19-39 years old), respectively. The estimation of glomerular filtration rate (eGFR) was determined using the Chronic Kidney Disease Epidemiology Collaboration formula and CKD was defined as <60 mL/min per 1.73m2 in this study.
Results: The cut-off values for grade I and II low HGS were 37.0 and 29.5 Kg for men and 21.5 and 16.8 Kg for women, respectively. The prevalence of grade II low HGS was 15.4% in a total population. Subjects with low HGS showed higher prevalence of diabetes, hypertension, and CKD than those with normal HGS (Table 1). There was a significant correlation between HGS and eGFR in both men and women (Figure 1.) In multivariate logistic regression adjusted by age group, diabetes, hypertension, and obesity, grade II low HGS showed an independent relationship with CKD in both men (OR 2.540, 95% CI 1.862-3.467) and women (OR 1.722, 95% CI 1.281-2.315) (Table 2).
Conclusions: The prevalence of CKD was higher in subjects with low HGS. Early detection of low HGS may be useful in assessing potential renal function impairment. |
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Table 1. Demographic and Clinical Characteristics of a Total Population According to Handgrip Strength
Table 2. Chronic Kidney Disease Prevalence According to Handgrip Strength
Figure 1. Scatter Plot Between Estimated Glomerular Filtration Rate and Handgrip Strength
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