| 제목 |
Therapeutic effects of rehabilitation therapy on controlling of Clostridium difficile infection |
| 소속 |
Daegu Catholic University Medical Center, Department of Rehabilitation Medicine1, Daegu Catholic University Medical Center, Department of Neurology2, Daegu Catholic University Medical Center, Department of Neurosurgery3 |
| 저자 |
Dong Rak Kwon1†, Gi Young Park1, Jin Kuk Do2, Jae Hoon Cho3, Dong Han Kim1*, Kang Lip Kim1 |
Objective: To assess the prevalence of Clostridium difficile (CD) infection and therapeutic effects of rehabilitation therapy on treatment duration of CD infection in patients with stroke at tertiary university hospital
Materials and Methods: This is retrospective study. One thousand five patients who transferred to rehabilitation department were recruited. One hundred twenty four out of 1005 stroke patients who were concordant for Clostridium difficile (C. difficile) positively on culture and presence of toxigenic strain. The patients (n=124) diagnosed with CD infection were divided into two groups (Figure 1). Group 1 (n=67) consisted of patients who were hospitalized in rehabilitation department with greater mobilization through rehabilitation therapy, and group 2 (n=57) was patients with lesser mobilization who were hospitalized in neurology and neurosurgery department. We compared the differences of several risk factors, the treatment method, and treatment duration between the two groups.
Results: There were no significant differences in demographics between two groups (Table 1). Among the risk factors related to CD infection, the period of use of antibiotics, H2 blocker, and enteral feeding was significantly higher in group 1 than that in group 2 (p<0.05, Table 2). The treatment duration of metronidazole PO medication was significantly shorter in group 1 than that in group 2 (p=0.011, Table 2)
Conclusions: This study showed that the group with rehabilitation therapy had shorter treatment duration of CD infection than that in the group without rehabilitation therapy. Rehabilitation therapy may be early and effectively controlling of CD infection in patients with stroke.
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Figure 1. Flowchart of the study protocol
Table 1. Patients demographics and initial clinical data of CD infection risk factors (N = 124)
Table 2. Comparison of the risk factors and the treatment duration of CD infection between two groups
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