| 제목 |
Effectiveness Of Physical Rehabilitation In Advanced Cancer Patients : A Systematic Review |
| 소속 |
Seoul National University Bundang Hospital, Department of Rehabilitation Medicine1, National Evidence-based Healthcare Collaborating Agency, Department of Others2, National Cancer Center, Department of Rehabilitation Medicine3 |
| 저자 |
Jangmi Yang2, JinA Choi2, Su-Yeon Yu2, Mi-Young Choi2, Ae Jung Jo2, Min Joo Kang2, Seung Hyun Chung3, Eun Joo Yang1*† |
Purpose: To evaluate the efficacy of supervised-exercise rehabilitation in advanced cancer patients from systematic reviews.
Methods: A systematic search of electronic databases, including MEDLINE, EMBASE and the Cochrane Library, as well as three domestic databases from inception to 3 July 2017, was performed. Two reviewers independently screened all references according to selection criteria. The Cochrane Risk of Bias (RoB) tool for randomized controlled trials (RCT), and the Risk of Bias for Non-randomized Studies (RoBANS) were used to assess quality of literature. Data from RCTs and pre-post studies were combined and meta-analysis was performed.
Results: A total of 11 studies were included. Four studies were RCTs and the remaining seven studies were pre-post studies respectively. Meta-analyses were performed by study design. For RCT meta-analyses, exercise interventions showed little reduction in fatigue compared to the control group with, standardized mean difference (SMD) of –0.62 and Confidence Interval (95% CI: –0.87 - 0.37). In meta-analyses for pre-post studies, exercise interventions resulted in improvements in muscular strength from baseline to follow-up: Leg press (mean difference (MD): 12.13, 95% CI: 5.90 - 18.35); Bench press (MD 4.81, 95% CI: 0.85 - 8.77); Abdominal crunch (MD 6.48; 95% CI: 2.01 to 10.96); Back (MD 5.18; 95% CI: 1.59 - 8.77). Exercise interventions have a positive impact on quality of life measured by EORTC-QLQ-C30 from baseline to follow-up (MD 9.86, 95% CI 1.56 -18.34).
Conclusions: Exercise may have beneficial effects on fatigue and be effective to improve muscular strength for advanced cancer patients based on existing studies. However, the positive results must be interpreted cautiously because of the heterogeneity of studies. More studies are needed to further investigate how to sustain positive effects of exercise over time.
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Effectiveness of rehabilitation on quality of life using systematic reviews with randomized controlled studies
Effectiveness of rehabilitation on physical performance using systematic reviews with pre-post studies
Effectiveness of rehabilitation on quality of life using systematic reviews with pre-post studies
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